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butabarbital will lessen the extent or influence of doravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.butabarbital will decrease the level or outcome of lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.near Make sure you affirm that you want to to Sign off of Medscape. For